To move an Item, simply click on it and drag it to a new position. The grid cell borders will be visible while the item is in motion. The grid cell aspect ratio is adaptive and depends on aspect ratio of the first item opened.
If the desired cell position is already occupied, the items will be swapped. If swapping is not possible due to too great a difference in item sizes or aspect ratio, the target cell(s) will be marked red:
If a bigger Item is being replaced by a smaller one, they will swap sizes as well as positions.
You can also use a right-click to move all Items in the layout at once, including the background image if there is one.